Version 5.4
Homo sapiens Gene: RIPK4
Summary
InnateDB Gene IDBG-3982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIPK4
Gene Name receptor-interacting serine-threonine kinase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183421
Encoded Proteins
IDBP-3984
receptor-interacting serine-threonine kinase 4
IDBP-3986
receptor-interacting serine-threonine kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:41739369-41767106
Strand Reverse strand
Band q22.3
Transcripts
ENST00000352483 ENSP00000330161
ENST00000332512 ENSP00000332454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0006468 protein phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005251
View Gene Order
ENSBTAG00000021251
Not yet available
Cross-References
SwissProt P57078
TrEMBL
UniProt Splice Variant
Entrez Gene 54101
UniGene Hs.517310
RefSeq NM_020639
HUGO HGNC:496
OMIM 605706
CCDS CCDS13675
HPRD 10419
IMGT
EMBL AB047783 AP001743
GenPept BAA95526 BAB56136
RNA Seq Atlas 54101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca