InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MALT1

Summary

InnateDB Gene

IDBG-3930.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MALT1

Gene Name

mucosa associated lymphoid tissue lymphoma translocation gene 1

Synonyms

IMD12; MLT; MLT1

Species

Homo sapiens

Ensembl Gene

ENSG00000172175

Encoded Proteins

IDBP-3932

mucosa associated lymphoid tissue lymphoma translocation gene 1

IDBP-3934

mucosa associated lymphoid tissue lymphoma translocation gene 1

IDBP-727541

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18192506

MALT1 forms a complex with CARM1 and BCL10 to activate NF-kappaB.

PMID 20804738

MALT1 is a paracaspase that has arginine-directed proteolytic activity. MALT1 cleaves TNFAIP3, a dual ubiquitin-editing enzyme involved in termination of NF-kappaB signalling, inducing cytosolic release of TNFAIP3 and dampening its inhibitory function.

Entrez Gene

Summary

This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:58671386-58750139

Strand

Forward strand

Band

q21.32

Transcripts

ENST00000348428	ENSP00000319279
ENST00000345724	ENSP00000304161
ENST00000589873
ENST00000591792	ENSP00000467222
ENST00000587438

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	61 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0019209	kinase activator activity
GO:0043621	protein self-association

Biological Process

GO:0001923	B-1 B cell differentiation
GO:0002237	response to molecule of bacterial origin
GO:0002726	positive regulation of T cell cytokine production
GO:0006508	proteolysis
GO:0006952	defense response
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0009620	response to fungus
GO:0016567	protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0032743	positive regulation of interleukin-2 production
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042098	T cell proliferation
GO:0042113	B cell activation
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0050852	T cell receptor signaling pathway
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051168	nuclear export
GO:0051259	protein oligomerization

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0032449	CBM complex
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm