Version 5.4
Homo sapiens Gene: MTMR3
Summary
InnateDB Gene IDBG-3909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTMR3
Gene Name myotubularin related protein 3
Synonyms FYVE-DSP1; ZFYVE10
Species Homo sapiens
Ensembl Gene ENSG00000100330
Encoded Proteins
IDBP-3911
myotubularin related protein 3
IDBP-3913
myotubularin related protein 3
IDBP-3952
myotubularin related protein 3
IDBP-294613
myotubularin related protein 3
IDBP-294608
myotubularin related protein 3
IDBP-371396
myotubularin related protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:29883155-30030866
Strand Forward strand
Band q12.2
Transcripts
ENST00000323630 ENSP00000318070
ENST00000351488 ENSP00000307271
ENST00000333027 ENSP00000331649
ENST00000401950 ENSP00000384651
ENST00000406629 ENSP00000384077
ENST00000445401 ENSP00000409063
ENST00000415511
ENST00000495098
ENST00000480776
ENST00000487907
ENST00000492087
ENST00000491251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0044281 small molecule metabolic process
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034354
View Gene Order
ENSBTAG00000001030
Not yet available
Pathways
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.474536 Hs.594472 Hs.599417
RefSeq NM_021090 NM_153050 NM_153051 XM_005261805 XM_005261807
HUGO
OMIM
CCDS CCDS13870 CCDS13871 CCDS46682
HPRD 09151
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca