Version 5.4
Homo sapiens Gene: GAS2L1
Summary
InnateDB Gene IDBG-3535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAS2L1
Gene Name growth arrest-specific 2 like 1
Synonyms GAR22
Species Homo sapiens
Ensembl Gene ENSG00000185340
Encoded Proteins
IDBP-294710
growth arrest-specific 2 like 1
IDBP-370589
growth arrest-specific 2 like 1
IDBP-370593
growth arrest-specific 2 like 1
IDBP-809407
growth arrest-specific 2 like 1
IDBP-809409
growth arrest-specific 2 like 1
IDBP-809411
growth arrest-specific 2 like 1
IDBP-809412
growth arrest-specific 2 like 1
IDBP-809416
growth arrest-specific 2 like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:29306582-29312785
Strand Forward strand
Band q12.2
Transcripts
ENST00000406549 ENSP00000383995
ENST00000416823 ENSP00000395988
ENST00000428622 ENSP00000388645
ENST00000487341
ENST00000491016
ENST00000616432 ENSP00000478908
ENST00000610653 ENSP00000484130
ENST00000621062 ENSP00000478343
ENST00000618518 ENSP00000481012
ENST00000611648 ENSP00000479551
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007050 cell cycle arrest
GO:0009267 cellular response to starvation
Cellular Component
GO:0001725 stress fiber
GO:0005874 microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034201
View Gene Order
ENSBTAG00000012504
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.322852
RefSeq NM_001278730 NM_006478 NM_152236
HUGO
OMIM
CCDS CCDS63438 CCDS74840
HPRD 03676
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca