Version 5.4
Homo sapiens Gene: HMGN1
Summary
InnateDB Gene IDBG-3514.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGN1
Gene Name high mobility group nucleosome binding domain 1
Synonyms HMG14
Species Homo sapiens
Ensembl Gene ENSG00000205581
Encoded Proteins
IDBP-3516
high mobility group nucleosome binding domain 1
IDBP-3518
high mobility group nucleosome binding domain 1
IDBP-3520
high mobility group nucleosome binding domain 1
IDBP-3522
high mobility group nucleosome binding domain 1
IDBP-366400
high mobility group nucleosome binding domain 1
IDBP-366422
high mobility group nucleosome binding domain 1
IDBP-366427
high mobility group nucleosome binding domain 1
IDBP-366436
high mobility group nucleosome binding domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:39342315-39349647
Strand Reverse strand
Band q22.2
Transcripts
ENST00000288344 ENSP00000288344
ENST00000380749 ENSP00000370125
ENST00000380748 ENSP00000370124
ENST00000380747 ENSP00000370123
ENST00000431390 ENSP00000395291
ENST00000436324 ENSP00000414421
ENST00000419378 ENSP00000396693
ENST00000443046 ENSP00000395787
ENST00000492280
ENST00000486741
ENST00000489072
ENST00000482192
ENST00000485550
ENST00000490032
ENST00000464078
ENST00000491183
ENST00000479586
ENST00000471260
ENST00000482733
ENST00000463631
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006325 chromatin organization
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010224 response to UV-B
GO:0010225 response to UV-C
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0040034 regulation of development, heterochronic
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0050678 regulation of epithelial cell proliferation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_23
TSH pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6NL93
UniProt Splice Variant
Entrez Gene 3150
UniGene Hs.356285 Hs.609993 Hs.625110
RefSeq NM_004965
HUGO HGNC:4984
OMIM 163920
CCDS CCDS33559
HPRD 01231
IMGT
EMBL AF064861
GenPept
RNA Seq Atlas 101927733 3150

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca