Version 5.4
Homo sapiens Gene: BRWD1
Summary
InnateDB Gene IDBG-3389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRWD1
Gene Name bromodomain and WD repeat domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185658
Encoded Proteins
IDBP-3393
bromodomain and WD repeat domain containing 1
IDBP-3397
bromodomain and WD repeat domain containing 1
IDBP-3399
bromodomain and WD repeat domain containing 1
IDBP-3403
bromodomain and WD repeat domain containing 1
IDBP-366267
bromodomain and WD repeat domain containing 1
IDBP-366312
bromodomain and WD repeat domain containing 1
IDBP-366321
bromodomain and WD repeat domain containing 1
IDBP-366325
bromodomain and WD repeat domain containing 1
IDBP-366327
bromodomain and WD repeat domain containing 1
IDBP-366330
bromodomain and WD repeat domain containing 1
IDBP-366333
bromodomain and WD repeat domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:39184176-39321559
Strand Reverse strand
Band q22.2
Transcripts
ENST00000333229 ENSP00000330753
ENST00000380800 ENSP00000370178
ENST00000342449 ENSP00000344333
ENST00000341322 ENSP00000342106
ENST00000446924 ENSP00000391014
ENST00000424441 ENSP00000415066
ENST00000445245 ENSP00000390684
ENST00000430093 ENSP00000393702
ENST00000445668 ENSP00000395575
ENST00000412604 ENSP00000398900
ENST00000455867 ENSP00000389882
ENST00000491564
ENST00000473813
ENST00000496759
ENST00000470108
ENST00000484090
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022914
View Gene Order
ENSBTAG00000013602
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.112582 Hs.463190 Hs.623405 Hs.627139 Hs.654740 Hs.713937 Hs.718269
RefSeq NM_001007246 NM_018963 NM_033656
HUGO
OMIM
CCDS CCDS13662 CCDS13663 CCDS33557
HPRD 11683
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca