Version 5.4
Homo sapiens Gene: ERG
Summary
InnateDB Gene IDBG-3269.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERG
Gene Name v-ets erythroblastosis virus E26 oncogene homolog (avian)
Synonyms erg-3; p55
Species Homo sapiens
Ensembl Gene ENSG00000157554
Encoded Proteins
IDBP-3273
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-231912
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-231916
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-231918
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-231920
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-231922
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-231926
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-365851
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-365853
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-365855
v-ets erythroblastosis virus E26 oncogene homolog (avian)
IDBP-365862
v-ets erythroblastosis virus E26 oncogene homolog (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2012]
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing\'s sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:38380027-38661780
Strand Reverse strand
Band q22.2
Transcripts
ENST00000288319 ENSP00000288319
ENST00000398919 ENSP00000381891
ENST00000398911 ENSP00000381882
ENST00000398910 ENSP00000381881
ENST00000398907 ENSP00000381879
ENST00000398905 ENSP00000381877
ENST00000398897 ENSP00000381871
ENST00000417133 ENSP00000414150
ENST00000442448 ENSP00000394694
ENST00000453032 ENSP00000396268
ENST00000429727 ENSP00000415659
ENST00000481609
ENST00000492833
ENST00000468474
ENST00000473107
ENST00000485493
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 151 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 151 [view]
Protein-Protein 142 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040732
View Gene Order
ENSBTAG00000011001
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.473819
RefSeq NM_001136154 NM_001136155 NM_001243428 NM_001243429 NM_001243432 NM_001291391 NM_004449 NM_182918
HUGO
OMIM
CCDS CCDS13657 CCDS13658 CCDS46648 CCDS46649 CCDS58789
HPRD 01298
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca