Homo sapiens Gene: DYRK1A | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-3163.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | DYRK1A | ||||||||||||||||||||||||
Gene Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | ||||||||||||||||||||||||
Synonyms | DYRK; DYRK1; HP86; MNB; MNBH; MRD7 | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000157540 | ||||||||||||||||||||||||
Encoded Proteins |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5\' UTR or in the 3\' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 21:37365790-37517450 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | q22.13 | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
Hedgehog pathway
TCR pathway
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REACTOME |
G0 and Early G1 pathway
Mitotic G1-G1/S phases pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
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KEGG | |||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
UniGene | Hs.368240 Hs.719974 | ||||||||||||||||||||||||
RefSeq | NM_001396 NM_101395 NM_130436 NM_130438 XM_005260931 XM_005260933 XM_006723976 XM_006723977 XM_006723978 XM_006723979 | ||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS13653 CCDS13654 CCDS42925 CCDS42926 | ||||||||||||||||||||||||
HPRD | 09018 | ||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||