InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADRBK2

Summary

InnateDB Gene

IDBG-3038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRBK2

Gene Name

adrenergic, beta, receptor kinase 2

Synonyms

BARK2; GRK3

Species

Homo sapiens

Ensembl Gene

ENSG00000100077

Encoded Proteins

IDBP-3040

adrenergic, beta, receptor kinase 2

IDBP-368282

adrenergic, beta, receptor kinase 2

IDBP-807104

adrenergic, beta, receptor kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85%% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95%% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:25564849-25729294

Strand

Forward strand

Band

q12.1

Transcripts

ENST00000324198	ENSP00000317578
ENST00000455558	ENSP00000393688
ENST00000619906	ENSP00000478925

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0047696	beta-adrenergic receptor kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0031623	receptor internalization
GO:0038032	termination of G-protein coupled receptor signaling pathway

Cellular Component

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042249

View Gene Order

ENSBTAG00000000005

Not yet available

Pathways

NETPATH

NetPath_16

IL4 pathway

REACTOME

KEGG

hsa04740

Olfactory transduction pathway

hsa04144

Endocytosis pathway

hsa04062

Chemokine signaling pathway pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

PID NCI

thrombin_par1_pathway

PAR1-mediated thrombin signaling events

Cross-References

SwissProt

P35626

TrEMBL

A0A024R1D8 Q8N433

UniProt Splice Variant

Entrez Gene

157

UniGene

Hs.657494

RefSeq

NM_005160 XM_006724158

HUGO

HGNC:290

OMIM

109636

CCDS

CCDS13832

HPRD

00183

IMGT

EMBL

AL022329 BC036797 CH471095 X69117

GenPept

AAH36797 CAA48870 CAB45657 EAW59699 EAW59700

RNA Seq Atlas

157