Version 5.4
Homo sapiens Gene: AJUBA
Summary
InnateDB Gene IDBG-2966.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AJUBA
Gene Name ajuba LIM protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000129474
Encoded Proteins
IDBP-2968
jub, ajuba homolog (Xenopus laevis)
IDBP-2970
jub, ajuba homolog (Xenopus laevis)
IDBP-235460
jub, ajuba homolog (Xenopus laevis)
IDBP-583738
jub, ajuba homolog (Xenopus laevis)
IDBP-595696
jub, ajuba homolog (Xenopus laevis)
IDBP-586327
jub, ajuba homolog (Xenopus laevis)
IDBP-587916
jub, ajuba homolog (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:22971174-22982642
Strand Reverse strand
Band q11.2
Transcripts
ENST00000262713 ENSP00000262713
ENST00000361265 ENSP00000354491
ENST00000397388 ENSP00000380543
ENST00000553592 ENSP00000452369
ENST00000556731 ENSP00000451649
ENST00000553911 ENSP00000452325
ENST00000555479
ENST00000553736 ENSP00000451772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0045294 alpha-catenin binding
GO:0051015 actin filament binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0001666 response to hypoxia
GO:0006351 transcription, DNA-templated
GO:0016339 calcium-dependent cell-cell adhesion
GO:0030032 lamellipodium assembly
GO:0030334 regulation of cell migration
GO:0031328 positive regulation of cellular biosynthetic process
GO:0031334 positive regulation of protein complex assembly
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0034613 cellular protein localization
GO:0035195 gene silencing by miRNA
GO:0035313 wound healing, spreading of epidermal cells
GO:0035331 negative regulation of hippo signaling
GO:0043087 regulation of GTPase activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0046474 glycerophospholipid biosynthetic process
GO:0048041 focal adhesion assembly
GO:1900037 regulation of cellular response to hypoxia
GO:2000637 positive regulation of gene silencing by miRNA
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022178
View Gene Order
ENSBTAG00000012724
Not yet available
Pathways
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
aurora_a_pathway
Aurora A signaling
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655832
RefSeq NM_032876 NM_198086
HUGO
OMIM
CCDS CCDS9581 CCDS9582
HPRD 16426
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca