Version 5.4
Homo sapiens Gene: ADORA2A
Summary
InnateDB Gene IDBG-2843.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADORA2A
Gene Name adenosine A2a receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128271
Encoded Proteins
IDBP-2847
adenosine A2a receptor
IDBP-367398
adenosine A2a receptor
IDBP-367399
adenosine A2a receptor
IDBP-367403
adenosine A2a receptor
IDBP-367406
adenosine A2a receptor
IDBP-813240
adenosine A2a receptor
IDBP-813241
adenosine A2a receptor
IDBP-813242
adenosine A2a receptor
IDBP-813246
adenosine A2a receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:24417879-24442360
Strand Forward strand
Band q11.23
Transcripts
ENST00000337539 ENSP00000336630
ENST00000424232 ENSP00000404497
ENST00000444262 ENSP00000414802
ENST00000436735 ENSP00000397071
ENST00000439591 ENSP00000400190
ENST00000467385
ENST00000486351
ENST00000486108 ENSP00000473799
ENST00000464977 ENSP00000474895
ENST00000496258 ENSP00000474097
ENST00000496497
ENST00000472248 ENSP00000475000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001609 G-protein coupled adenosine receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
Biological Process
GO:0006171 cAMP biosynthetic process
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007267 cell-cell signaling
GO:0007417 central nervous system development
GO:0007596 blood coagulation
GO:0007600 sensory perception
GO:0008015 blood circulation
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020178
View Gene Order
ENSBTAG00000016944
Not yet available
Pathways
NETPATH
REACTOME
REACT_11046
NGF-independant TRKA activation pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_18288
Adenosine P1 receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_11061
Signalling by NGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_21340
GPCR ligand binding pathway
REACT_11064
Activation of TRKA receptors pathway
REACT_18342
Nucleotide-like (purinergic) receptors pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
hsa05012
Parkinson's disease pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
hif2pathway
HIF-2-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.197029 Hs.691096
RefSeq NM_000675 NM_001278499
HUGO
OMIM
CCDS CCDS13826
HPRD 00043
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca