Version 5.4
| Homo sapiens Gene: SLC2A11 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-2604.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SLC2A11 | ||||||||||||||||||
| Gene Name | solute carrier family 2 (facilitated glucose transporter), member 11 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000133460 | ||||||||||||||||||
| Encoded Proteins |
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
solute carrier family 2 (facilitated glucose transporter), member 11
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
MIF;SLC2A11 interacts with ribosomal protein S19 (RPS19) leading to attenuation of MIF pro-inflammatory function by inhibition of the MIF-CD74 interaction and MIF triggered adhesion of monocytes.
MIF;SLC2A11 is a regulator of innate immunity and inflammation by having an important role in pro-inflammatory macrophage responses. Transcription factors specificity protein 1 (SP1) and cAMP response element-binding protein (CREB1) are critical positive regulators of its constitutive gene expression.
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| Entrez Gene | |||||||||||||||||||
| Summary |
SLC2A11 belongs to a family of plasma membrane proteins that mediate transport of sugars across the membrane by facilitative diffusion (Sasaki et al., 2001 [PubMed 11741323]).[supplied by OMIM, Mar 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 22:23856703-23886309 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q11.23 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Class II GLUTs pathway
Facilitative Na+-independent glucose transporters pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Transmembrane transport of small molecules pathway
SLC-mediated transmembrane transport pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | B5MCM7 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 66035 | ||||||||||||||||||
| UniGene | Hs.661910 Hs.743282 | ||||||||||||||||||
| RefSeq | NM_001024938 NM_001024939 NM_001282864 NM_030807 | ||||||||||||||||||
| HUGO | HGNC:14239 | ||||||||||||||||||
| OMIM | 610367 | ||||||||||||||||||
| CCDS | CCDS13818 CCDS33616 CCDS46673 CCDS74828 | ||||||||||||||||||
| HPRD | 11571 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AP000350 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 66035 | ||||||||||||||||||