Version 5.4
Homo sapiens Gene: NDRG2
Summary
InnateDB Gene IDBG-2444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDRG2
Gene Name NDRG family member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165795
Encoded Proteins
IDBP-2446
NDRG family member 2
IDBP-2448
NDRG family member 2
IDBP-2450
NDRG family member 2
IDBP-2452
NDRG family member 2
IDBP-234248
NDRG family member 2
IDBP-234250
NDRG family member 2
IDBP-234254
NDRG family member 2
IDBP-234256
NDRG family member 2
IDBP-234258
NDRG family member 2
IDBP-234260
NDRG family member 2
IDBP-292512
NDRG family member 2
IDBP-360888
NDRG family member 2
IDBP-586901
NDRG family member 2
IDBP-591145
NDRG family member 2
IDBP-591902
NDRG family member 2
IDBP-599812
NDRG family member 2
IDBP-596963
NDRG family member 2
IDBP-583652
NDRG family member 2
IDBP-595357
NDRG family member 2
IDBP-603572
NDRG family member 2
IDBP-596036
NDRG family member 2
IDBP-596850
NDRG family member 2
IDBP-598223
NDRG family member 2
IDBP-600019
NDRG family member 2
IDBP-600417
NDRG family member 2
IDBP-585020
NDRG family member 2
IDBP-603046
NDRG family member 2
IDBP-585169
NDRG family member 2
IDBP-599424
NDRG family member 2
IDBP-603574
NDRG family member 2
IDBP-588825
NDRG family member 2
IDBP-595230
NDRG family member 2
IDBP-584760
NDRG family member 2
IDBP-586338
NDRG family member 2
IDBP-598431
NDRG family member 2
IDBP-600440
NDRG family member 2
IDBP-586690
NDRG family member 2
IDBP-584869
NDRG family member 2
IDBP-590651
NDRG family member 2
IDBP-588093
NDRG family member 2
IDBP-595979
NDRG family member 2
IDBP-599739
NDRG family member 2
IDBP-591233
NDRG family member 2
IDBP-591696
NDRG family member 2
IDBP-591457
NDRG family member 2
IDBP-594444
NDRG family member 2
IDBP-597908
NDRG family member 2
IDBP-592615
NDRG family member 2
IDBP-588192
NDRG family member 2
IDBP-590882
NDRG family member 2
IDBP-588410
NDRG family member 2
IDBP-595340
NDRG family member 2
IDBP-589667
NDRG family member 2
IDBP-602836
NDRG family member 2
IDBP-592683
NDRG family member 2
IDBP-595501
NDRG family member 2
IDBP-583442
NDRG family member 2
IDBP-596384
NDRG family member 2
IDBP-590261
NDRG family member 2
IDBP-599195
NDRG family member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:21016763-21070872
Strand Reverse strand
Band q11.2
Transcripts
ENST00000298687 ENSP00000298687
ENST00000350792 ENSP00000344620
ENST00000360463 ENSP00000353649
ENST00000298684 ENSP00000298684
ENST00000366204
ENST00000397858 ENSP00000380956
ENST00000397856 ENSP00000380954
ENST00000397853 ENSP00000380951
ENST00000397851 ENSP00000380949
ENST00000397847 ENSP00000380945
ENST00000397844 ENSP00000380943
ENST00000403829 ENSP00000385889
ENST00000449431 ENSP00000397250
ENST00000556716
ENST00000557633 ENSP00000450835
ENST00000554104 ENSP00000452216
ENST00000555158 ENSP00000452038
ENST00000553503 ENSP00000452306
ENST00000556147 ENSP00000451712
ENST00000557353 ENSP00000450446
ENST00000554143 ENSP00000452006
ENST00000555650
ENST00000553593 ENSP00000452117
ENST00000553793
ENST00000556008 ENSP00000451966
ENST00000557416
ENST00000556366 ENSP00000452413
ENST00000556974 ENSP00000452362
ENST00000555026 ENSP00000451274
ENST00000554277
ENST00000553867 ENSP00000450691
ENST00000557169 ENSP00000452334
ENST00000555695 ENSP00000451353
ENST00000555869 ENSP00000451105
ENST00000557182 ENSP00000450545
ENST00000555733 ENSP00000452482
ENST00000555384 ENSP00000451094
ENST00000554094 ENSP00000452278
ENST00000553741
ENST00000557728
ENST00000553567
ENST00000557305
ENST00000557198
ENST00000553442 ENSP00000450493
ENST00000556420 ENSP00000451951
ENST00000553784 ENSP00000451059
ENST00000557149 ENSP00000452592
ENST00000555142 ENSP00000450513
ENST00000555767 ENSP00000452053
ENST00000554531 ENSP00000451302
ENST00000557264 ENSP00000451471
ENST00000557676 ENSP00000452548
ENST00000556924 ENSP00000450504
ENST00000556329 ENSP00000452262
ENST00000554379 ENSP00000450929
ENST00000554398 ENSP00000451185
ENST00000554472 ENSP00000451348
ENST00000554483 ENSP00000451472
ENST00000555657 ENSP00000452247
ENST00000557616 ENSP00000451414
ENST00000557274 ENSP00000452344
ENST00000556457 ENSP00000450852
ENST00000556688 ENSP00000451981
ENST00000553862
ENST00000557669
ENST00000557113
ENST00000553900
ENST00000557318
ENST00000554561 ENSP00000451163
ENST00000554419 ENSP00000452179
ENST00000553563 ENSP00000451541
ENST00000554489 ENSP00000452302
ENST00000556561 ENSP00000450825
ENST00000554893 ENSP00000450450
ENST00000554833 ENSP00000452458
ENST00000554415 ENSP00000452274
ENST00000557167
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0001818 negative regulation of cytokine production
GO:0007165 signal transduction
GO:0010574 regulation of vascular endothelial growth factor production
GO:0016055 Wnt signaling pathway
GO:0021762 substantia nigra development
GO:0030154 cell differentiation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0090361 regulation of platelet-derived growth factor production
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0030426 growth cone
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004558
View Gene Order
ENSBTAG00000000843
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL G3V239 G3V280 G3V3C3 G3V3X3 G3V5A6 G3V5D7 G3V5G7 G3V5V9
UniProt Splice Variant
Entrez Gene 57447
UniGene Hs.525205
RefSeq NM_001282211 NM_001282212 NM_001282213 NM_001282214 NM_001282215 NM_001282216 NM_016250 NM_201535 NM_201536 NM_201537 NM_201538 NM_201539 NM_201540 NM_201541
HUGO HGNC:14460
OMIM 605272
CCDS CCDS61384 CCDS61386 CCDS73613 CCDS9564 CCDS9565
HPRD 17630
IMGT
EMBL AL161668
GenPept
RNA Seq Atlas 57447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca