InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: YWHAG

Summary

InnateDB Gene

IDBG-23145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YWHAG

Gene Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

Synonyms

14-3-3GAMMA; PPP1R170

Species

Homo sapiens

Ensembl Gene

ENSG00000170027

Encoded Proteins

IDBP-23147

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100%% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:76326794-76359031

Strand

Reverse strand

Band

q11.23

Transcripts

ENST00000307630

ENSP00000306330

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 347 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	347 [view]
Protein-Protein	345 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0008426	protein kinase C inhibitor activity
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006469	negative regulation of protein kinase activity
GO:0006605	protein targeting
GO:0006915	apoptotic process
GO:0009966	regulation of signal transduction
GO:0045664	regulation of neuron differentiation
GO:0048167	regulation of synaptic plasticity
GO:0061024	membrane organization
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway