Version 5.4
Homo sapiens Gene: EIF3C
Summary
InnateDB Gene IDBG-23122.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3C
Gene Name eukaryotic translation initiation factor 3, subunit C
Synonyms eIF3-p110; EIF3CL; EIF3S8
Species Homo sapiens
Ensembl Gene ENSG00000184110
Encoded Proteins
IDBP-23124
eukaryotic translation initiation factor 3, subunit C
IDBP-239234
eukaryotic translation initiation factor 3, subunit C
IDBP-749252
IDBP-746560
IDBP-750953
IDBP-750774
IDBP-749955
IDBP-753516
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:28688558-28735730
Strand Forward strand
Band p11.2
Transcripts
ENST00000331666 ENSP00000332604
ENST00000395587 ENSP00000378953
ENST00000568426 ENSP00000455277
ENST00000565932
ENST00000566501 ENSP00000457963
ENST00000566519
ENST00000569690 ENSP00000455278
ENST00000565099
ENST00000563139 ENSP00000457389
ENST00000564839
ENST00000564243 ENSP00000456416
ENST00000566866 ENSP00000457418
ENST00000569005
ENST00000566086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 124 [view]
Protein-Protein 122 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030738
View Gene Order
ENSBTAG00000006543
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt Q99613
TrEMBL A0A024QYU9 A0A024QYX7 B3KNZ4 B4DVQ5 H3BPE3 H3BPE4 H3BTY8
UniProt Splice Variant
Entrez Gene 8663
UniGene Hs.567374 Hs.661687
RefSeq NM_001037808 NM_001267574 NM_003752 NM_001199142 NM_001286478
HUGO HGNC:3279
OMIM 603916
CCDS CCDS10638 CCDS66993
HPRD 04889
IMGT
EMBL AC002544 AC145285 AK000739 AK055366 AK292155 AK301183 BC000533 BC001571 BC071705 BC157842 BC157849 BT007335 CH878380 U46025 U91326
GenPept AAC27426 AAC27674 AAD03462 AAH00533 AAH01571 AAH71705 AAI57843 AAI57850 AAP35999 BAA91352 BAF84844 BAG51506 BAG62767 EAW50492 EAW50493 EAW50494 EAW50495 EAW50496
RNA Seq Atlas 8663

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca