Version 5.4
Homo sapiens Gene: EOMES
Summary
InnateDB Gene IDBG-23119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EOMES
Gene Name eomesodermin
Synonyms TBR2
Species Homo sapiens
Ensembl Gene ENSG00000163508
Encoded Proteins
IDBP-23121
eomesodermin
IDBP-368931
eomesodermin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. [provided by RefSeq, Jul 2008]
This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:27715949-27722711
Strand Reverse strand
Band p24.1
Transcripts
ENST00000295743 ENSP00000295743
ENST00000449599 ENSP00000388620
ENST00000461503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001191 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001706 endoderm formation
GO:0001707 mesoderm formation
GO:0001714 endodermal cell fate specification
GO:0001824 blastocyst development
GO:0001829 trophectodermal cell differentiation
GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007420 brain development
GO:0010002 cardioblast differentiation
GO:0010468 regulation of gene expression
GO:0019827 stem cell maintenance
GO:0021772 olfactory bulb development
GO:0021796 cerebral cortex regionalization
GO:0021895 cerebral cortex neuron differentiation
GO:0030154 cell differentiation
GO:0032609 interferon-gamma production
GO:0035914 skeletal muscle cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045664 regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050767 regulation of neurogenesis
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0060809 mesodermal to mesenchymal transition involved in gastrulation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032446
View Gene Order
ENSBTAG00000016920
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.147279 Hs.591663 Hs.734211
RefSeq NM_001278182 NM_001278183 NM_005442
HUGO
OMIM
CCDS CCDS2646 CCDS63585
HPRD 07054
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca