InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MDH2

Summary

InnateDB Gene

IDBG-22995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDH2

Gene Name

malate dehydrogenase 2, NAD (mitochondrial)

Synonyms

M-MDH; MDH; MGC:3559; MOR1

Species

Homo sapiens

Ensembl Gene

ENSG00000146701

Encoded Proteins

IDBP-22997

malate dehydrogenase 2, NAD (mitochondrial)

IDBP-379712

malate dehydrogenase 2, NAD (mitochondrial)

IDBP-379713

malate dehydrogenase 2, NAD (mitochondrial)

IDBP-809362

malate dehydrogenase 2, NAD (mitochondrial)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. [provided by RefSeq, Jul 2008]
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:76048051-76067508

Strand

Forward strand

Band

q11.23

Transcripts

ENST00000315758	ENSP00000327070
ENST00000424167
ENST00000443006	ENSP00000416929
ENST00000432020	ENSP00000408649
ENST00000461263	ENSP00000475583
ENST00000461665
ENST00000490105
ENST00000492663

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016615	malate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060	L-malate dehydrogenase activity
GO:0043621	protein self-association
GO:0044822	poly(A) RNA binding
GO:0046554	malate dehydrogenase (NADP+) activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006099	tricarboxylic acid cycle
GO:0006107	oxaloacetate metabolic process
GO:0006108	malate metabolic process
GO:0006475	internal protein amino acid acetylation
GO:0006734	NADH metabolic process
GO:0044237	cellular metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome