Version 5.4
Homo sapiens Gene: RECQL
Summary
InnateDB Gene IDBG-22845.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RECQL
Gene Name RecQ protein-like (DNA helicase Q1-like)
Synonyms RecQ1; RECQL1
Species Homo sapiens
Ensembl Gene ENSG00000004700
Encoded Proteins
IDBP-22847
RecQ protein-like (DNA helicase Q1-like)
IDBP-238216
RecQ protein-like (DNA helicase Q1-like)
IDBP-369239
RecQ protein-like (DNA helicase Q1-like)
IDBP-369241
RecQ protein-like (DNA helicase Q1-like)
IDBP-602613
RecQ protein-like (DNA helicase Q1-like)
IDBP-596479
RecQ protein-like (DNA helicase Q1-like)
IDBP-583529
RecQ protein-like (DNA helicase Q1-like)
IDBP-594680
RecQ protein-like (DNA helicase Q1-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5\' and 3\' UTRs, have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21468911-21501669
Strand Reverse strand
Band p12.1
Transcripts
ENST00000314748 ENSP00000318727
ENST00000396093 ENSP00000379400
ENST00000444129 ENSP00000416739
ENST00000421138 ENSP00000395449
ENST00000542432 ENSP00000445555
ENST00000536240 ENSP00000439069
ENST00000536964 ENSP00000446036
ENST00000539672 ENSP00000440700
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 21 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0036310 annealing helicase activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity
Biological Process
GO:0000733 DNA strand renaturation
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030243
View Gene Order
ENSBTAG00000021083
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.235069
RefSeq NM_002907 NM_032941 XM_005253461 XM_005253462 XM_005253463 XM_005253464 XM_006719133
HUGO
OMIM
CCDS CCDS31756
HPRD 02762
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca