Version 5.4
Homo sapiens Gene: DCK
Summary
InnateDB Gene IDBG-22842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCK
Gene Name deoxycytidine kinase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156136
Encoded Proteins
IDBP-22844
deoxycytidine kinase
IDBP-477502
deoxycytidine kinase
IDBP-481402
deoxycytidine kinase
IDBP-480365
deoxycytidine kinase
IDBP-484760
deoxycytidine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:70992538-71030914
Strand Forward strand
Band q13.3
Transcripts
ENST00000286648 ENSP00000286648
ENST00000509617 ENSP00000422971
ENST00000503359 ENSP00000426389
ENST00000504730 ENSP00000425578
ENST00000504952 ENSP00000421508
ENST00000509764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 22 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004137 deoxycytidine kinase activity
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019206 nucleoside kinase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006144 purine nucleobase metabolic process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0043097 pyrimidine nucleoside salvage
GO:0043101 purine-containing compound salvage
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029366
View Gene Order
ENSBTAG00000012397
Not yet available
Pathways
NETPATH
REACTOME
REACT_655
Pyrimidine salvage reactions pathway
REACT_1923
Purine salvage pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.613252 Hs.641645 Hs.709
RefSeq NM_000788
HUGO
OMIM
CCDS CCDS3548
HPRD 00507
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca