InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SDCBP

Summary

InnateDB Gene

IDBG-22706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDCBP

Gene Name

syndecan binding protein (syntenin)

Synonyms

MDA-9; MDA9; ST1; SYCL; TACIP18

Species

Homo sapiens

Ensembl Gene

ENSG00000137575

Encoded Proteins

IDBP-22708

syndecan binding protein (syntenin)

IDBP-371089

syndecan binding protein (syntenin)

IDBP-371090

syndecan binding protein (syntenin)

IDBP-371091

syndecan binding protein (syntenin)

IDBP-371102

syndecan binding protein (syntenin)

IDBP-473491

syndecan binding protein (syntenin)

IDBP-484367

syndecan binding protein (syntenin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:58552924-58582860

Strand

Forward strand

Band

q12.1

Transcripts

ENST00000260130	ENSP00000260130
ENST00000413219	ENSP00000411771
ENST00000447182	ENSP00000409288
ENST00000424270	ENSP00000395351
ENST00000447267	ENSP00000397820
ENST00000522243
ENST00000523483	ENSP00000428184
ENST00000520168	ENSP00000430730
ENST00000519115
ENST00000522843
ENST00000520228
ENST00000523441

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005109	frizzled binding
GO:0005137	interleukin-5 receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008093	cytoskeletal adaptor activity
GO:0019838	growth factor binding
GO:0042043	neurexin family protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0045545	syndecan binding
GO:0046875	ephrin receptor binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0006612	protein targeting to membrane
GO:0006930	substrate-dependent cell migration, cell extension
GO:0007265	Ras protein signal transduction
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0030036	actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0042327	positive regulation of phosphorylation
GO:0046330	positive regulation of JNK cascade

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005895	interleukin-5 receptor complex
GO:0005912	adherens junction
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle