Version 5.4
Homo sapiens Gene: SLCO1B1
Summary
InnateDB Gene IDBG-22549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLCO1B1
Gene Name solute carrier organic anion transporter family, member 1B1
Synonyms HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6
Species Homo sapiens
Ensembl Gene ENSG00000134538
Encoded Proteins
IDBP-22551
solute carrier organic anion transporter family, member 1B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21131202-21239246
Strand Forward strand
Band p12.1
Transcripts
ENST00000256958 ENSP00000256958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0015347 sodium-independent organic anion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0008206 bile acid metabolic process
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0043252 sodium-independent organic anion transport
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_23988
Transport of organic anions pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_11042
Recycling of bile acids and salts pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt Q9Y6L6
TrEMBL A0A024RAU7 K4P403
UniProt Splice Variant
Entrez Gene 10599
UniGene Hs.449738
RefSeq NM_006446
HUGO HGNC:10959
OMIM 604843
CCDS CCDS8685
HPRD
IMGT
EMBL AB026257 AF060500 AF205071 AJ132573 AJ400749 AJ400750 AJ400751 AJ400752 AJ400753 AJ400754 AJ400755 AJ400756 AJ400757 AJ400758 AJ400759 AJ400760 AJ400761 AJ400762 AK312970 AY945934 BC114376 CH471094 JX547014
GenPept AAD38323 AAF20212 AAI14377 AAX20114 AFV58025 BAA78639 BAG35809 CAB62577 CAB97007 EAW96420 EAW96421
RNA Seq Atlas 10599

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca