InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE3A

Summary

InnateDB Gene

IDBG-22315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE3A

Gene Name

phosphodiesterase 3A, cGMP-inhibited

Synonyms

CGI-PDE; CGI-PDE A; CGI-PDE-A

Species

Homo sapiens

Ensembl Gene

ENSG00000172572

Encoded Proteins

IDBP-22317

phosphodiesterase 3A, cGMP-inhibited

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:20369245-20684381

Strand

Forward strand

Band

p12.2

Transcripts

ENST00000359062	ENSP00000351957
ENST00000542675
ENST00000544307

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004119	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0001556	oocyte maturation
GO:0006198	cAMP catabolic process
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0016101	diterpenoid metabolic process
GO:0019933	cAMP-mediated signaling
GO:0019934	cGMP-mediated signaling
GO:0040020	regulation of meiosis
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043116	negative regulation of vascular permeability
GO:0043117	positive regulation of vascular permeability
GO:0051591	response to cAMP
GO:0060282	positive regulation of oocyte development
GO:0071321	cellular response to cGMP
GO:0071560	cellular response to transforming growth factor beta stimulus