Version 5.4
Homo sapiens Gene: CLK3
Summary
InnateDB Gene IDBG-22269.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLK3
Gene Name CDC-like kinase 3
Synonyms PHCLK3; PHCLK3/152
Species Homo sapiens
Ensembl Gene ENSG00000179335
Encoded Proteins
IDBP-22271
CDC-like kinase 3
IDBP-240297
CDC-like kinase 3
IDBP-588136
CDC-like kinase 3
IDBP-746963
IDBP-746074
IDBP-746988
IDBP-747141
IDBP-745901
IDBP-747210
IDBP-747720
IDBP-745510
IDBP-745274
IDBP-747326
IDBP-745839
IDBP-747544
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:74598500-74645414
Strand Forward strand
Band q24.1
Transcripts
ENST00000345005 ENSP00000344112
ENST00000395066 ENSP00000378505
ENST00000454830
ENST00000483723 ENSP00000431825
ENST00000566126 ENSP00000457696
ENST00000562670 ENSP00000455905
ENST00000570296
ENST00000567992
ENST00000568605
ENST00000569063 ENSP00000456278
ENST00000562389 ENSP00000456399
ENST00000568488 ENSP00000457936
ENST00000561673
ENST00000564096 ENSP00000458099
ENST00000563842 ENSP00000456202
ENST00000563112
ENST00000563418 ENSP00000456431
ENST00000568232
ENST00000567805
ENST00000564468 ENSP00000454785
ENST00000562078
ENST00000562626
ENST00000568139 ENSP00000455762
ENST00000564353
ENST00000569406
ENST00000566926 ENSP00000454961
ENST00000563297 ENSP00000457362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043484 regulation of RNA splicing
GO:0046777 protein autophosphorylation
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032316
View Gene Order
ENSBTAG00000007304
Not yet available
Cross-References
SwissProt
TrEMBL H3BRT8 H3BUL5 H3BVF8
UniProt Splice Variant
Entrez Gene 1198
UniGene Hs.511790 Hs.732460
RefSeq NM_001130028 NM_003992 XM_005254153 XM_005254154
HUGO HGNC:2071
OMIM 602990
CCDS CCDS10265 CCDS45304
HPRD 04290
IMGT
EMBL AC100835
GenPept
RNA Seq Atlas 1198

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca