InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EMR1

Summary

InnateDB Gene

IDBG-22184.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EMR1

Gene Name

egf-like module containing, mucin-like, hormone receptor-like 1

Synonyms

TM7LN3

Species

Homo sapiens

Ensembl Gene

ENSG00000174837

Encoded Proteins

IDBP-22186

egf-like module containing, mucin-like, hormone receptor-like 1

IDBP-22188

egf-like module containing, mucin-like, hormone receptor-like 1

IDBP-22190

egf-like module containing, mucin-like, hormone receptor-like 1

IDBP-22192

egf-like module containing, mucin-like, hormone receptor-like 1

IDBP-367990

egf-like module containing, mucin-like, hormone receptor-like 1

IDBP-765230

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6887566-6940459

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000250572	ENSP00000250572
ENST00000381407	ENSP00000370814
ENST00000312053	ENSP00000311545
ENST00000381404	ENSP00000370811
ENST00000450315	ENSP00000405974
ENST00000595026	ENSP00000472553
ENST00000596944
ENST00000601198

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0071944	cell periphery

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004730

View Gene Order

ENSBTAG00000007901

Not yet available

Pathways

NETPATH

REACTOME

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_21340

GPCR ligand binding pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.2375

RefSeq

NM_001256252 NM_001256253 NM_001256254 NM_001256255 NM_001974

HUGO

OMIM

CCDS

CCDS12175 CCDS58643 CCDS58644 CCDS58645 CCDS58646

HPRD

02733

IMGT

EMBL

GenPept

RNA Seq Atlas