Version 5.4
Homo sapiens Gene: RPL15
Summary
InnateDB Gene IDBG-22156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPL15
Gene Name ribosomal protein L15
Synonyms DBA12; EC45; L15; RPL10; RPLY10; RPYL10
Species Homo sapiens
Ensembl Gene ENSG00000174748
Encoded Proteins
IDBP-22158
ribosomal protein L15
IDBP-22160
ribosomal protein L15
IDBP-367830
ribosomal protein L15
IDBP-367832
ribosomal protein L15
IDBP-367835
ribosomal protein L15
IDBP-367838
ribosomal protein L15
IDBP-367848
ribosomal protein L15
IDBP-367851
ribosomal protein L15
IDBP-367862
ribosomal protein L15
IDBP-367871
ribosomal protein L15
IDBP-813469
ribosomal protein L15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:23916545-23923692
Strand Forward strand
Band p24.2
Transcripts
ENST00000354811 ENSP00000346867
ENST00000307839 ENSP00000309334
ENST00000422218 ENSP00000387925
ENST00000434031 ENSP00000405590
ENST00000413699 ENSP00000416692
ENST00000412097 ENSP00000411176
ENST00000435882 ENSP00000390193
ENST00000415719 ENSP00000388529
ENST00000456530 ENSP00000398788
ENST00000436146 ENSP00000408243
ENST00000490223
ENST00000465786
ENST00000611050 ENSP00000483260
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
Experimentally validated
Total 128 [view]
Protein-Protein 126 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1986
Eukaryotic Translation Termination pathway
REACT_1404
Peptide chain elongation pathway
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_9491
Viral mRNA Translation pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_6167
Influenza Infection pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_6145
Influenza Life Cycle pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa03010
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.381219 Hs.630818 Hs.742264
RefSeq NM_001253379 NM_001253380 NM_001253382 NM_001253383 NM_001253384 NM_002948
HUGO
OMIM
CCDS CCDS2640 CCDS58818
HPRD 16043
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca