Version 5.4
Homo sapiens Gene: RXFP2
Summary
InnateDB Gene IDBG-22013.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RXFP2
Gene Name relaxin/insulin-like family peptide receptor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133105
Encoded Proteins
IDBP-22015
relaxin/insulin-like family peptide receptor 2
IDBP-22017
relaxin/insulin-like family peptide receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:31739542-31803388
Strand Forward strand
Band q13.1
Transcripts
ENST00000298386 ENSP00000298386
ENST00000380314 ENSP00000369670
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016500 protein-hormone receptor activity
GO:0017046 peptide hormone binding
Biological Process
GO:0001556 oocyte maturation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053368
View Gene Order
ENSBTAG00000015132
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_21314
Relaxin receptors pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.616925 Hs.680763
RefSeq NM_001166058 NM_130806
HUGO
OMIM
CCDS CCDS53862 CCDS9342
HPRD 05976
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca