Version 5.4
Homo sapiens Gene: MAP3K1
Summary
InnateDB Gene IDBG-22000.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP3K1
Gene Name mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Synonyms MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6
Species Homo sapiens
Ensembl Gene ENSG00000095015
Encoded Proteins
IDBP-230467
mitogen-activated protein kinase kinase kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18984593
MAP3K1 and TRAF6 play a pivotal role in the retinoic-acid-inducible gene-I (RIG-I)-like helicase antiviral pathway.
Entrez Gene
Summary The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:56815574-56896152
Strand Forward strand
Band q11.2
Transcripts
ENST00000399503 ENSP00000382423
ENST00000469188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 108 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 108 [view]
Protein-Protein 105 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0008545 JUN kinase kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0003382 epithelial cell morphogenesis
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0008637 apoptotic mitochondrial changes
GO:0030334 regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042060 wound healing
GO:0043010 camera-type eye development
GO:0045087 innate immune response (InnateDB)
GO:0061029 eyelid development in camera-type eye
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021754
View Gene Order
ENSBTAG00000013790
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
REACTOME
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
cd40_pathway
CD40/CD40L signaling
ceramide_pathway
Ceramide signaling pathway
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
caspase_pathway
Caspase Cascade in Apoptosis
tnfpathway
TNF receptor signaling pathway
trail_pathway
TRAIL signaling pathway
erbb1_downstream_pathway
ErbB1 downstream signaling
rac1_pathway
RAC1 signaling pathway
bcr_5pathway
BCR signaling pathway
tcrjnkpathway
JNK signaling in the CD4+ TCR pathway
cdc42_pathway
CDC42 signaling events
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
smad2_3pathway
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
ifngpathway
IFN-gamma pathway
avb3_opn_pathway
Osteopontin-mediated events
faspathway
FAS (CD95) signaling pathway
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt Q13233
TrEMBL
UniProt Splice Variant
Entrez Gene 4214
UniGene Hs.653654
RefSeq NM_005921 XM_005248519 XM_005248520
HUGO HGNC:6848
OMIM 600982
CCDS CCDS43318
HPRD
IMGT
EMBL AC008937 AF042838 U29671
GenPept AAB05828 AAC97073
RNA Seq Atlas 4214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca