Version 5.4
Homo sapiens Gene: PIK3C2G
Summary
InnateDB Gene IDBG-21909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3C2G
Gene Name phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Synonyms PI3K-C2-gamma; PI3K-C2GAMMA
Species Homo sapiens
Ensembl Gene ENSG00000139144
Encoded Proteins
IDBP-21911
phosphoinositide-3-kinase, class 2, gamma polypeptide
IDBP-368575
phosphoinositide-3-kinase, class 2, gamma polypeptide
IDBP-600441
phosphoinositide-3-kinase, class 2, gamma polypeptide
IDBP-586261
phosphoinositide-3-kinase, class 2, gamma polypeptide
IDBP-812810
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
IDBP-599179
phosphoinositide-3-kinase, class 2, gamma polypeptide
IDBP-812812
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:18247614-18648416
Strand Forward strand
Band p12.3
Transcripts
ENST00000266497 ENSP00000266497
ENST00000433979 ENSP00000404845
ENST00000535651 ENSP00000443850
ENST00000546003 ENSP00000441618
ENST00000536967 ENSP00000479145
ENST00000538458
ENST00000538779 ENSP00000445381
ENST00000621090 ENSP00000481702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006935 chemotaxis
GO:0008150 biological_process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030228
View Gene Order
ENSBTAG00000020715
Not yet available
Pathways
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5288
UniGene
RefSeq NM_001288772 NM_001288774 NM_004570 XM_005253393 XM_006719088
HUGO HGNC:8973
OMIM 609001
CCDS CCDS44839 CCDS73452
HPRD
IMGT
EMBL AC087236 AC087240 AC091815 AC092851 AJ000008 BC130277 CH471094
GenPept AAI30278 CAA03853 EAW96387
RNA Seq Atlas 5288

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca