Version 5.4
Homo sapiens Gene: TEP1
Summary
InnateDB Gene IDBG-2183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TEP1
Gene Name telomerase-associated protein 1
Synonyms p240; TLP1; TP1; TROVE1; VAULT2
Species Homo sapiens
Ensembl Gene ENSG00000129566
Encoded Proteins
IDBP-2185
telomerase-associated protein 1
IDBP-594938
telomerase-associated protein 1
IDBP-584491
telomerase-associated protein 1
IDBP-600884
telomerase-associated protein 1
IDBP-588623
telomerase-associated protein 1
IDBP-585687
telomerase-associated protein 1
IDBP-588362
telomerase-associated protein 1
IDBP-591130
telomerase-associated protein 1
IDBP-590034
telomerase-associated protein 1
IDBP-589868
telomerase-associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:20365667-20413429
Strand Reverse strand
Band q11.2
Transcripts
ENST00000262715 ENSP00000262715
ENST00000471684 ENSP00000451919
ENST00000553365 ENSP00000450475
ENST00000555008 ENSP00000450541
ENST00000555727 ENSP00000451634
ENST00000556935 ENSP00000452574
ENST00000553984 ENSP00000450508
ENST00000557314 ENSP00000450830
ENST00000556488 ENSP00000451409
ENST00000557627
ENST00000556549 ENSP00000452240
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003720 telomerase activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000722 telomere maintenance via recombination
GO:0006278 RNA-dependent DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005697 telomerase holoenzyme complex
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006281
View Gene Order
ENSBTAG00000001179
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 7011
UniGene Hs.508835 Hs.604805
RefSeq NM_007110 XM_005268027
HUGO HGNC:11726
OMIM 601686
CCDS CCDS9548
HPRD 03404
IMGT
EMBL
GenPept
RNA Seq Atlas 7011

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca