InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: C3

Summary

InnateDB Gene

IDBG-21798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

complement component 3

Synonyms

AHUS5; ARMD9; ASP; C3a; C3b; CPAMD1; HEL-S-62p

Species

Homo sapiens

Ensembl Gene

ENSG00000125730

Encoded Proteins

IDBP-21800

complement component 3

IDBP-761492

IDBP-762464

IDBP-762180

IDBP-764400

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 16875735

Central protein of the complement system; Classical, lectin and alternative pathways of complement all converge at the activation of C3 yielding a diverse set of biological responses

PMID 24315997

T cell-expressed CTSL1 cleaves C3 into active C3a and C3b fragments mediating the intracellular and extracellular C3 activation in T cells.

InnateDB Annotation from Orthologs

Summary

PMID 24273177

[Mus musculus] C3a and its receptor C3ar1 are critical for defense against C. psittaci in mouse lung infection.

Entrez Gene

Summary

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6677704-6730562

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000245907	ENSP00000245907
ENST00000596179
ENST00000602053
ENST00000597442
ENST00000601475
ENST00000599668
ENST00000602229	ENSP00000469482
ENST00000599899
ENST00000594005
ENST00000598805
ENST00000601008	ENSP00000471384
ENST00000600763
ENST00000596238
ENST00000596548	ENSP00000469744
ENST00000594936
ENST00000594270
ENST00000595577
ENST00000600744	ENSP00000472044

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0031715	C5L2 anaphylatoxin chemotactic receptor binding

Biological Process

GO:0001798	positive regulation of type IIa hypersensitivity
GO:0001934	positive regulation of protein phosphorylation
GO:0001970	positive regulation of activation of membrane attack complex
GO:0006631	fatty acid metabolic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010828	positive regulation of glucose transport
GO:0010866	regulation of triglyceride biosynthetic process
GO:0010884	positive regulation of lipid storage
GO:0010951	negative regulation of endopeptidase activity
GO:0030449	regulation of complement activation
GO:0045087	innate immune response (InnateDB)
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0050766	positive regulation of phagocytosis
GO:0050776	regulation of immune response
GO:2000427	positive regulation of apoptotic cell clearance

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle