Version 5.4
| Homo sapiens Gene: TOP3B | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-2166.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TOP3B | ||||||||||||||||||
| Gene Name | topoisomerase (DNA) III beta | ||||||||||||||||||
| Synonyms | TOP3B1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000100038 | ||||||||||||||||||
| Encoded Proteins |
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
topoisomerase (DNA) III beta
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 22:21957025-21982816 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q11.22 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Homologous recombination pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | H7C4B0 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 8940 | ||||||||||||||||||
| UniGene | Hs.194685 Hs.436401 | ||||||||||||||||||
| RefSeq | NM_001282112 NM_001282113 NM_003935 XM_005261811 XM_005261814 XM_006724349 XM_006724350 XM_006724351 XM_006724352 | ||||||||||||||||||
| HUGO | HGNC:11993 | ||||||||||||||||||
| OMIM | 603582 | ||||||||||||||||||
| CCDS | CCDS13797 | ||||||||||||||||||
| HPRD | 04662 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | D87012 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 8940 | ||||||||||||||||||