Version 5.4
Homo sapiens Gene: DERL2
Summary
InnateDB Gene IDBG-21628.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DERL2
Gene Name derlin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072849
Encoded Proteins
IDBP-21632
Der1-like domain family, member 2
IDBP-759561
IDBP-760674
IDBP-761230
IDBP-762119
IDBP-760685
IDBP-760595
IDBP-764144
IDBP-758529
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:5471251-5486811
Strand Reverse strand
Band p13.2
Transcripts
ENST00000158771 ENSP00000158771
ENST00000576551 ENSP00000467794
ENST00000574952 ENSP00000459154
ENST00000574700
ENST00000570848 ENSP00000459072
ENST00000571971 ENSP00000458296
ENST00000573637 ENSP00000458448
ENST00000575605 ENSP00000459083
ENST00000571968
ENST00000571476 ENSP00000461603
ENST00000575209
ENST00000572834 ENSP00000460671
ENST00000573547
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001967 suckling behavior
GO:0008284 positive regulation of cell proliferation
GO:0030307 positive regulation of cell growth
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0030970 retrograde protein transport, ER to cytosol
Cellular Component
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018442
View Gene Order
ENSBTAG00000020431
Not yet available
Pathways
NETPATH
REACTOME
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_228209
Hh ligand biogenesis disease pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_116125
Disease pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.594522 Hs.730726
RefSeq NM_016041 XM_005256672
HUGO
OMIM
CCDS CCDS11073
HPRD 16796
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca