Version 5.4
Homo sapiens Gene: CKB
Summary
InnateDB Gene IDBG-21613.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKB
Gene Name creatine kinase, brain
Synonyms B-CK; BCK; CKBB; HEL-211; HEL-S-29
Species Homo sapiens
Ensembl Gene ENSG00000166165
Encoded Proteins
IDBP-21615
creatine kinase, brain
IDBP-583793
creatine kinase, brain
IDBP-593601
creatine kinase, brain
IDBP-594109
creatine kinase, brain
IDBP-593480
creatine kinase, brain
IDBP-589873
creatine kinase, brain
IDBP-593639
creatine kinase, brain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103519659-103523111
Strand Reverse strand
Band q32.33
Transcripts
ENST00000348956 ENSP00000299198
ENST00000554989 ENSP00000451680
ENST00000554282
ENST00000553528
ENST00000553652 ENSP00000450676
ENST00000553610 ENSP00000451426
ENST00000555039 ENSP00000451686
ENST00000555366
ENST00000557569
ENST00000554426
ENST00000553878 ENSP00000451904
ENST00000557287
ENST00000555659
ENST00000554705
ENST00000555770
ENST00000557530 ENSP00000451611
ENST00000553994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 59 [view]
Protein-Protein 59 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004111 creatine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006600 creatine metabolic process
GO:0007420 brain development
GO:0016310 phosphorylation
GO:0021762 substantia nigra development
GO:0030644 cellular chloride ion homeostasis
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001270
View Gene Order
ENSBTAG00000035998
Not yet available
Pathways
NETPATH
REACTOME
REACT_813
Creatine metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1152
UniGene
RefSeq NM_001823
HUGO HGNC:1991
OMIM 123280
CCDS CCDS9981
HPRD 00423
IMGT
EMBL
GenPept
RNA Seq Atlas 1152

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca