InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SATB1

Summary

InnateDB Gene

IDBG-21555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SATB1

Gene Name

SATB homeobox 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000182568

Encoded Proteins

IDBP-21557

SATB homeobox 1

IDBP-367089

SATB homeobox 1

IDBP-367098

SATB homeobox 1

IDBP-367102

SATB homeobox 1

IDBP-367110

SATB homeobox 1

IDBP-367112

SATB homeobox 1

IDBP-367117

SATB homeobox 1

IDBP-367121

SATB homeobox 1

IDBP-367125

SATB homeobox 1

IDBP-367129

SATB homeobox 1

IDBP-807596

SATB homeobox 1

IDBP-807602

SATB homeobox 1

IDBP-602247

SATB homeobox 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:18345387-18445588

Strand

Reverse strand

Band

p24.3

Transcripts

ENST00000338745	ENSP00000341024
ENST00000454909	ENSP00000399708
ENST00000417717	ENSP00000399518
ENST00000440737	ENSP00000402982
ENST00000452260	ENSP00000406727
ENST00000415069	ENSP00000390529
ENST00000457005	ENSP00000398072
ENST00000414509	ENSP00000408871
ENST00000444341	ENSP00000391344
ENST00000450898	ENSP00000394520
ENST00000476178
ENST00000467628
ENST00000475083	ENSP00000480000
ENST00000482788
ENST00000491519	ENSP00000479866
ENST00000493952	ENSP00000453908
ENST00000487699
ENST00000606296

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0008544	epidermis development
GO:0016032	viral process
GO:0016571	histone methylation
GO:0042110	T cell activation
GO:0043367	CD4-positive, alpha-beta T cell differentiation
GO:0043374	CD8-positive, alpha-beta T cell differentiation
GO:0050798	activated T cell proliferation
GO:0060004	reflex

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005720	nuclear heterochromatin
GO:0016363	nuclear matrix
GO:0016605	PML body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023927

View Gene Order

ENSBTAG00000021158

Not yet available

Pathways

NETPATH

REACTOME

REACT_107

Apoptotic cleavage of cellular proteins pathway

REACT_995

Apoptotic execution phase pathway

REACT_578

Apoptosis pathway

KEGG

INOH

PID NCI

caspase_pathway

Caspase Cascade in Apoptosis

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.517717 Hs.593276 Hs.629483 Hs.630427 Hs.674678

RefSeq

NM_001131010 NM_001195470 NM_002971 XM_006713280 XM_006713281

HUGO

OMIM

CCDS

CCDS2631 CCDS56242

HPRD

03647

IMGT

EMBL

GenPept

RNA Seq Atlas