Version 5.4
Homo sapiens Gene: MAPK1
Summary
InnateDB Gene IDBG-2147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK1
Gene Name mitogen-activated protein kinase 1
Synonyms ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2
Species Homo sapiens
Ensembl Gene ENSG00000100030
Encoded Proteins
IDBP-2149
mitogen-activated protein kinase 1
IDBP-232140
mitogen-activated protein kinase 1
IDBP-589204
mitogen-activated protein kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22447027
MAPK1 (ERK) and MAPK14 (p38) control the dynamic balance regulating neutrophil migration.
InnateDB Annotation from Orthologs
Summary
PMID 22447027
[Mus musculus] Mapk1 (ERK) and Mapk14 (p38) control the dynamic balance regulating neutrophil migration. (Demonstrated in human)
PMID 25538234
[Mus musculus] Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
PMID 25757564
[Mus musculus] Prostaglandin E2 transactivates Csf1r and synergizes with its signalling at Mapk1/Mapk3 level in promoting macrophage migration.
Entrez Gene
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:21754500-21867680
Strand Reverse strand
Band q11.22
Transcripts
ENST00000215832 ENSP00000215832
ENST00000398822 ENSP00000381803
ENST00000491588
ENST00000544786 ENSP00000440842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 359 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 359 [view]
Protein-Protein 356 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0003677 DNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0000189 MAPK import into nucleus
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0006950 response to stress
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009636 response to toxic substance
GO:0009887 organ morphogenesis
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0016032 viral process
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019233 sensory perception of pain
GO:0019858 cytosine metabolic process
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0031647 regulation of protein stability
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032872 regulation of stress-activated MAPK cascade
GO:0033598 mammary gland epithelial cell proliferation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035556 intracellular signal transduction
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0038127 ERBB signaling pathway
GO:0043330 response to exogenous dsRNA
GO:0043627 response to estrogen
GO:0045087 innate immune response (InnateDB)
GO:0045596 negative regulation of cell differentiation
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0051493 regulation of cytoskeleton organization
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060716 labyrinthine layer blood vessel development
GO:0070371 ERK1 and ERK2 cascade
GO:0070849 response to epidermal growth factor
GO:0071310 cellular response to organic substance
GO:0072584 caveolin-mediated endocytosis
GO:0090170 regulation of Golgi inheritance
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:2000641 regulation of early endosome to late endosome transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0015630 microtubule cytoskeleton
GO:0030424 axon
GO:0031143 pseudopodium
GO:0032839 dendrite cytoplasm
GO:0043204 perikaryon
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063358
View Gene Order
ENSBTAG00000010312
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
NetPath_5
ID pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_20
IL9 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
NetPath_25
FSH pathway
NetPath_26
TWEAK pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_1100
Golgi Cisternae Pericentriolar Stack Reorganization pathway
REACT_1183
ERK2 activation pathway
REACT_1482
ERK activation pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_25195
Advanced glycosylation endproduct receptor signaling pathway
REACT_12436
ERKs are inactivated pathway
REACT_12599
ERK/MAPK targets pathway
REACT_21326
Activation of the AP-1 family of transcription factors pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_111133
Growth hormone receptor signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_12033
Signalling to RAS pathway
REACT_524
SOS-mediated signalling pathway
REACT_508
Signal attenuation pathway
REACT_12579
SHC1 events in EGFR signaling pathway
REACT_12606
GRB2 events in EGFR signaling pathway
REACT_9417
Signaling by EGFR pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_15466
phospho-PLA2 pathway pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_661
SHC-mediated signalling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150139
SHC-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_20510
RSK activation pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_999
SHC-related events pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_13685
Neuronal System pathway
REACT_12529
Signaling by VEGF pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_634
RAF/MAP kinase cascade pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_332
IRS-mediated signalling pathway
REACT_15526
G-protein mediated events pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_200819
Cellular response to heat stress pathway
REACT_762
IRS-related events pathway
REACT_765
Mitotic Prophase pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_15307
Ca-dependent events pathway
REACT_116125
Disease pathway
REACT_169118
Signaling by Leptin pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04150
mTOR signaling pathway pathway
hsa04912
GnRH signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04540
Gap junction pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa04360
Axon guidance pathway
hsa05216
Thyroid cancer pathway
hsa04520
Adherens junction pathway
hsa05213
Endometrial cancer pathway
hsa04720
Long-term potentiation pathway
hsa05219
Bladder cancer pathway
hsa05010
Alzheimer's disease pathway
hsa05214
Glioma pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04730
Long-term depression pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04916
Melanogenesis pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04320
Dorso-ventral axis formation pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05020
Prion diseases pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04114
Oocyte meiosis pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
IGF1 signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
PDGF signaling pathway pathway
PID NCI
ar_nongenomic_pathway
Nongenotropic Androgen signaling
ceramide_pathway
Ceramide signaling pathway
bmppathway
BMP receptor signaling
ps1pathway
Presenilin action in Notch and Wnt signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
pi3kcibpathway
Class IB PI3K non-lipid kinase events
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.431850 Hs.592187
RefSeq NM_002745 NM_138957
HUGO
OMIM
CCDS CCDS13795
HPRD 01496
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca