Version 5.4
Homo sapiens Gene: PTPRO
Summary
InnateDB Gene IDBG-21457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRO
Gene Name protein tyrosine phosphatase, receptor type, O
Synonyms GLEPP1; NPHS6; PTP-OC; PTP-U2; PTPROT; PTPU2; R-PTP-O
Species Homo sapiens
Ensembl Gene ENSG00000151490
Encoded Proteins
IDBP-21459
protein tyrosine phosphatase, receptor type, O
IDBP-21461
protein tyrosine phosphatase, receptor type, O
IDBP-368294
protein tyrosine phosphatase, receptor type, O
IDBP-368338
protein tyrosine phosphatase, receptor type, O
IDBP-597157
protein tyrosine phosphatase, receptor type, O
IDBP-585213
protein tyrosine phosphatase, receptor type, O
IDBP-601094
protein tyrosine phosphatase, receptor type, O
IDBP-584445
protein tyrosine phosphatase, receptor type, O
IDBP-587764
protein tyrosine phosphatase, receptor type, O
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:15322397-15597399
Strand Forward strand
Band p12.3
Transcripts
ENST00000281171 ENSP00000281171
ENST00000348962 ENSP00000343434
ENST00000442921 ENSP00000404188
ENST00000445537 ENSP00000393449
ENST00000543886 ENSP00000444173
ENST00000545023
ENST00000542557 ENSP00000437571
ENST00000544244 ENSP00000439234
ENST00000535311 ENSP00000445621
ENST00000538907
ENST00000535322 ENSP00000446201
ENST00000544706
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0017147 Wnt-protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000902 cell morphogenesis
GO:0002548 monocyte chemotaxis
GO:0003093 regulation of glomerular filtration
GO:0003105 negative regulation of glomerular filtration
GO:0006470 protein dephosphorylation
GO:0007411 axon guidance
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010977 negative regulation of neuron projection development
GO:0016311 dephosphorylation
GO:0030032 lamellipodium assembly
GO:0032835 glomerulus development
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0036060 slit diaphragm assembly
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090260 negative regulation of retinal ganglion cell axon guidance
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030426 growth cone
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030223
View Gene Order
ENSBTAG00000006256
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt Q16827
TrEMBL A0A024RAS9 B4DS16
UniProt Splice Variant
Entrez Gene 5800
UniGene Hs.160871
RefSeq NM_030669 NM_002848 NM_030667 NM_030668 NM_030670 NM_030671
HUGO HGNC:9678
OMIM 600579
CCDS CCDS44837 CCDS53754 CCDS8674 CCDS8675
HPRD 02784
IMGT
EMBL AC007542 AC022334 AC092183 AF187043 AF187044 AK290982 AK299529 BC035960 BC126201 BC126203 CH471094 U20489 Z48541
GenPept AAA82892 AAF04086 AAF04087 AAH35960 AAI26202 AAI26204 BAF83671 BAG61478 CAA88425 EAW96349 EAW96350 EAW96351 EAW96352
RNA Seq Atlas 5800

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca