InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KHSRP

Summary

InnateDB Gene

IDBG-21386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KHSRP

Gene Name

KH-type splicing regulatory protein

Synonyms

FBP2; FUBP2; KSRP

Species

Homo sapiens

Ensembl Gene

ENSG00000088247

Encoded Proteins

IDBP-233748

KH-type splicing regulatory protein

IDBP-760023

IDBP-765235

IDBP-765355

IDBP-762726

IDBP-765666

IDBP-761872

IDBP-764390

IDBP-765725

IDBP-809102

KH-type splicing regulatory protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21690298

KHSRP directly interacts with AU-rich elements in the 3' UTR of IFN mRNA to negatively regulate the transcript levels. Khsrp deficient mouse embryonic fibroblast produced higher levels of Ifna4 and Ifnb mRNAs in response to viral infections as a result of decreased mRNA decay.

InnateDB Annotation from Orthologs

Summary

PMID 21690298

[Mus musculus] Khsrp directly interacts with AU-rich elements in the 3' UTR of Ifn mRNA to negatively regulate the transcript levels. Khsrp deficient mouse embryonic fibroblast produced higher levels of Ifna4 and Ifnb mRNAs in response to viral infections as a result of decreased mRNA decay.

Entrez Gene

Summary

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6413348-6424794

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000398148	ENSP00000381216
ENST00000595112
ENST00000600480	ENSP00000471146
ENST00000599395	ENSP00000471262
ENST00000599642
ENST00000595548	ENSP00000469830
ENST00000594496	ENSP00000472347
ENST00000597656	ENSP00000472328
ENST00000595223	ENSP00000473254
ENST00000595258	ENSP00000469431
ENST00000594745	ENSP00000469804
ENST00000597704
ENST00000619396	ENSP00000478033

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	71 [view]
Protein-DNA	4 [view]
Protein-RNA	11 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006402	mRNA catabolic process
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051028	mRNA transport
GO:2000628	regulation of miRNA metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000007670

View Gene Order

ENSBTAG00000021018

Not yet available

Pathways

NETPATH

REACTOME

REACT_25042

KSRP destabilizes mRNA pathway

REACT_18355

ATF4 activates genes pathway

REACT_18277

PERK regulates gene expression pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.727344

RefSeq

NM_003685

HUGO

OMIM

CCDS

CCDS45936

HPRD

10350

IMGT

EMBL

GenPept

RNA Seq Atlas