InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LAT2

Summary

InnateDB Gene

IDBG-21069.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAT2

Gene Name

linker for activation of T cells family, member 2

Synonyms

LAB; NTAL; WBSCR15; WBSCR5; WSCR5

Species

Homo sapiens

Ensembl Gene

ENSG00000086730

Encoded Proteins

IDBP-21071

linker for activation of T cells family, member 2

IDBP-21073

linker for activation of T cells family, member 2

IDBP-21075

linker for activation of T cells family, member 2

IDBP-232899

linker for activation of T cells family, member 2

IDBP-485146

linker for activation of T cells family, member 2

IDBP-480778

linker for activation of T cells family, member 2

IDBP-474918

linker for activation of T cells family, member 2

IDBP-593109

linker for activation of T cells family, member 2

IDBP-482908

linker for activation of T cells family, member 2

IDBP-812918

linker for activation of T cells family, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:74199652-74229834

Strand

Forward strand

Band

q11.23

Transcripts

ENST00000275635	ENSP00000275635
ENST00000344995	ENSP00000344881
ENST00000361082	ENSP00000354374
ENST00000398475	ENSP00000381492
ENST00000465116	ENSP00000420549
ENST00000460943	ENSP00000420494
ENST00000491595
ENST00000475494	ENSP00000417533
ENST00000488266	ENSP00000433807
ENST00000470709	ENSP00000419150
ENST00000490586
ENST00000612664	ENSP00000483925

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042169	SH2 domain binding

Biological Process

GO:0019722	calcium-mediated signaling
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042113	B cell activation
GO:0043303	mast cell degranulation
GO:0045087	innate immune response
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0042629	mast cell granule
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000040751

View Gene Order

Pathways

NETPATH

NetPath_12

BCR pathway

REACTOME

REACT_163769

Role of LAT2/NTAL/LAB on calcium mobilization pathway

REACT_6802

Innate Immune System pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

fcer1pathway

Fc-epsilon receptor I signaling in mast cells

Cross-References

SwissProt

Q9GZY6

TrEMBL

C9JA24 C9JDY7 F8W947

UniProt Splice Variant

Entrez Gene

7462

UniGene

RefSeq

XM_005250562 NM_014146 NM_032463 NM_032464

HUGO

HGNC:12749

OMIM

605719

CCDS

CCDS5566

HPRD

09304

IMGT

EMBL

AC005081 AF045555 AF161531 AF252611 AF252612 AF252613 AF252614 AF257135 AK002099 AK092904 AK290074 AK290916 AY190023 BC001609 BC009204 CH471200

GenPept

AAF29018 AAF74978 AAF91352 AAH01609 AAH09204 AAK37429 AAK37430 AAK37431 AAK37633 AAO63155 AAS07404 AAS07405 BAA92084 BAF82763 BAF83605 BAG52627 EAW69610 EAW69611 EAW69612 EAW69613

RNA Seq Atlas

7462