Version 5.4
Homo sapiens Gene: LPHN3
Summary
InnateDB Gene IDBG-20730.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPHN3
Gene Name latrophilin 3
Synonyms CIRL3; LEC3
Species Homo sapiens
Ensembl Gene ENSG00000150471
Encoded Proteins
IDBP-478257
latrophilin 3
IDBP-474484
latrophilin 3
IDBP-480475
latrophilin 3
IDBP-482874
latrophilin 3
IDBP-475057
latrophilin 3
IDBP-474013
latrophilin 3
IDBP-482518
latrophilin 3
IDBP-476003
latrophilin 3
IDBP-476809
latrophilin 3
IDBP-474765
latrophilin 3
IDBP-480288
latrophilin 3
IDBP-483759
latrophilin 3
IDBP-475165
latrophilin 3
IDBP-482618
latrophilin 3
IDBP-484588
latrophilin 3
IDBP-596937
latrophilin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:61201258-62078335
Strand Forward strand
Band q13.1
Transcripts
ENST00000512091 ENSP00000423388
ENST00000509779
ENST00000514591 ENSP00000422533
ENST00000509896 ENSP00000423787
ENST00000511324 ENSP00000425033
ENST00000506700 ENSP00000424120
ENST00000507164 ENSP00000421476
ENST00000508693 ENSP00000424030
ENST00000507625 ENSP00000421372
ENST00000514157 ENSP00000425201
ENST00000504896 ENSP00000423434
ENST00000508946 ENSP00000421627
ENST00000506720 ENSP00000420931
ENST00000506746 ENSP00000425884
ENST00000514996 ENSP00000424258
ENST00000509089
ENST00000502815 ENSP00000424402
ENST00000508078
ENST00000545650 ENSP00000439831
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037605
View Gene Order
ENSBTAG00000013918
Not yet available
Cross-References
SwissProt
TrEMBL Q4W5J9
UniProt Splice Variant
Entrez Gene 23284
UniGene Hs.570770 Hs.740160
RefSeq NM_015236 XM_006714153 XM_006714154 XM_006714155 XM_006714156
HUGO HGNC:20974
OMIM
CCDS CCDS54768
HPRD 10055
IMGT
EMBL AC096723
GenPept AAY40992
RNA Seq Atlas 23284

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca