InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLDN3

Summary

InnateDB Gene

IDBG-20433.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN3

Gene Name

claudin 3

Synonyms

C7orf1; CPE-R2; CPETR2; HRVP1; RVP1

Species

Homo sapiens

Ensembl Gene

ENSG00000165215

Encoded Proteins

IDBP-240165

claudin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:73768997-73770270

Strand

Reverse strand

Band

q11.23

Transcripts

ENST00000395145

ENSP00000378577

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0007165	signal transduction
GO:0016338	calcium-independent cell-cell adhesion

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0016328	lateral plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000070473

View Gene Order

ENSBTAG00000040432

Not yet available

Pathways

NETPATH

REACTOME

REACT_19373

Tight junction interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

REACT_19331

Cell-cell junction organization pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04530

Tight junction pathway

hsa05160

Hepatitis C pathway

INOH

PID NCI

Cross-References

SwissProt

O15551

TrEMBL

Q75L79

UniProt Splice Variant

Entrez Gene

1365

UniGene

Hs.647023

RefSeq

NM_001306

HUGO

HGNC:2045

OMIM

602910

CCDS

CCDS5559

HPRD

IMGT

EMBL

AB000714 AC093168 AF007189 AK313276 BC016056 CH471200

GenPept

AAC78277 AAH16056 AAS07555 BAA22986 BAG36084 EAW69641

RNA Seq Atlas

1365