InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGA2

Summary

InnateDB Gene

IDBG-20326.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA2

Gene Name

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

Synonyms

BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2

Species

Homo sapiens

Ensembl Gene

ENSG00000164171

Encoded Proteins

IDBP-20328

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

IDBP-474240

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

IDBP-482034

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

IDBP-482017

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

IDBP-481770

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

IDBP-478496

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:52989326-53094779

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000296585	ENSP00000296585
ENST00000503810	ENSP00000426489
ENST00000513685	ENSP00000422095
ENST00000509960	ENSP00000424642
ENST00000509814	ENSP00000424397
ENST00000510722	ENSP00000422145

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	31 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0032403	protein complex binding
GO:0038064	collagen receptor activity
GO:0043236	laminin binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0002687	positive regulation of leukocyte migration
GO:0006928	cellular component movement
GO:0006929	substrate-dependent cell migration
GO:0006971	hypotonic response
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0009612	response to mechanical stimulus
GO:0009615	response to virus
GO:0009887	organ morphogenesis
GO:0010634	positive regulation of epithelial cell migration
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0014850	response to muscle activity
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016032	viral process
GO:0030198	extracellular matrix organization
GO:0030879	mammary gland development
GO:0031346	positive regulation of cell projection organization
GO:0031589	cell-substrate adhesion
GO:0032870	cellular response to hormone stimulus
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033343	positive regulation of collagen binding
GO:0033591	response to L-ascorbic acid
GO:0033627	cell adhesion mediated by integrin
GO:0038065	collagen-activated signaling pathway
GO:0042060	wound healing
GO:0042493	response to drug
GO:0043388	positive regulation of DNA binding
GO:0043589	skin morphogenesis
GO:0045184	establishment of protein localization
GO:0045727	positive regulation of translation
GO:0045785	positive regulation of cell adhesion
GO:0045987	positive regulation of smooth muscle contraction
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0050927	positive regulation of positive chemotaxis
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0070365	hepatocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009279	cell outer membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0042995	cell projection
GO:0043679	axon terminus
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm