InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STX1A

Summary

InnateDB Gene

IDBG-20282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX1A

Gene Name

syntaxin 1A (brain)

Synonyms

HPC-1; P35-1; STX1; SYN1A

Species

Homo sapiens

Ensembl Gene

ENSG00000106089

Encoded Proteins

IDBP-20284

syntaxin 1A (brain)

IDBP-240118

syntaxin 1A (brain)

IDBP-240120

syntaxin 1A (brain)

IDBP-240122

syntaxin 1A (brain)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:73699206-73719672

Strand

Reverse strand

Band

q11.23

Transcripts

ENST00000222812	ENSP00000222812
ENST00000395156	ENSP00000378585
ENST00000395155	ENSP00000378584
ENST00000395154	ENSP00000378583
ENST00000484736
ENST00000480126
ENST00000491645
ENST00000497980
ENST00000491427
ENST00000496216
ENST00000461441
ENST00000470878
ENST00000494245
ENST00000462135

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	66 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0001948	glycoprotein binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0017022	myosin binding
GO:0019855	calcium channel inhibitor activity
GO:0019904	protein domain specific binding
GO:0030674	protein binding, bridging
GO:0032028	myosin head/neck binding
GO:0043008	ATP-dependent protein binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001956	positive regulation of neurotransmitter secretion
GO:0006112	energy reserve metabolic process
GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0009629	response to gravity
GO:0014047	glutamate secretion
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0016192	vesicle-mediated transport
GO:0017156	calcium ion-dependent exocytosis
GO:0017157	regulation of exocytosis
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0045921	positive regulation of exocytosis
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030141	secretory granule
GO:0030672	synaptic vesicle membrane
GO:0031201	SNARE complex
GO:0042641	actomyosin
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0043234	protein complex
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex