InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC20A2

Summary

InnateDB Gene

IDBG-20276.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC20A2

Gene Name

solute carrier family 20 (phosphate transporter), member 2

Synonyms

GLVR-2; GLVR2; IBGC1; IBGC3; MLVAR; PIT-2; PIT2; RAM1

Species

Homo sapiens

Ensembl Gene

ENSG00000168575

Encoded Proteins

IDBP-20278

solute carrier family 20 (phosphate transporter), member 2

IDBP-480113

solute carrier family 20 (phosphate transporter), member 2

IDBP-476438

solute carrier family 20 (phosphate transporter), member 2

IDBP-476713

solute carrier family 20 (phosphate transporter), member 2

IDBP-484912

solute carrier family 20 (phosphate transporter), member 2

IDBP-478290

solute carrier family 20 (phosphate transporter), member 2

IDBP-482929

solute carrier family 20 (phosphate transporter), member 2

IDBP-477446

solute carrier family 20 (phosphate transporter), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:42416475-42541926

Strand

Reverse strand

Band

p11.21

Transcripts

ENST00000342228	ENSP00000340465
ENST00000520262	ENSP00000429754
ENST00000520179	ENSP00000429712
ENST00000518660
ENST00000522401
ENST00000524211	ENSP00000429989
ENST00000518717	ENSP00000430166
ENST00000517366	ENSP00000427756
ENST00000522707	ENSP00000429299
ENST00000518384	ENSP00000430462
ENST00000524237
ENST00000523340
ENST00000519463
ENST00000521455

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004872	receptor activity
GO:0005315	inorganic phosphate transmembrane transporter activity
GO:0005436	sodium:phosphate symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006817	phosphate ion transport
GO:0009615	response to virus
GO:0016032	viral process
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037656

View Gene Order

ENSBTAG00000014861

Not yet available

Pathways

NETPATH

REACTOME

REACT_19275

Sodium-coupled phosphate cotransporters pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.653173

RefSeq

NM_001257180 NM_001257181 NM_006749 XM_005273613

HUGO

OMIM

CCDS

CCDS6132

HPRD

08865

IMGT

EMBL

GenPept

RNA Seq Atlas