InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SCNN1B

Summary

InnateDB Gene

IDBG-20271.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCNN1B

Gene Name

sodium channel, non-voltage-gated 1, beta subunit

Synonyms

BESC1; ENaCb; ENaCbeta; SCNEB

Species

Homo sapiens

Ensembl Gene

ENSG00000168447

Encoded Proteins

IDBP-20273

sodium channel, nonvoltage-gated 1, beta

IDBP-20275

sodium channel, nonvoltage-gated 1, beta

IDBP-751763

IDBP-811838

sodium channel, non-voltage-gated 1, beta subunit

IDBP-748489

IDBP-750778

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:23278231-23381299

Strand

Forward strand

Band

p12.2

Transcripts

ENST00000343070	ENSP00000345751
ENST00000307331	ENSP00000302874
ENST00000568923	ENSP00000456309
ENST00000566441	ENSP00000482681
ENST00000564275	ENSP00000457754
ENST00000566870
ENST00000566647
ENST00000568085	ENSP00000455673
ENST00000569789

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0050699	WW domain binding

Biological Process

GO:0006814	sodium ion transport
GO:0007588	excretion
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050891	multicellular organismal water homeostasis
GO:0050896	response to stimulus
GO:0050909	sensory perception of taste
GO:0055078	sodium ion homeostasis
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0034706	sodium channel complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030873

View Gene Order

ENSBTAG00000012290

Not yet available

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

hsa04742

Taste transduction pathway

hsa04960

Aldosterone-regulated sodium reabsorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.414614

RefSeq

NM_000336 XM_005255467

HUGO

OMIM

CCDS

CCDS10609

HPRD

02861

IMGT

EMBL

GenPept

RNA Seq Atlas