Version 5.4
Homo sapiens Gene: VDAC3
Summary
InnateDB Gene IDBG-20244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VDAC3
Gene Name voltage-dependent anion channel 3
Synonyms HD-VDAC3; VDAC-3
Species Homo sapiens
Ensembl Gene ENSG00000078668
Encoded Proteins
IDBP-20246
voltage-dependent anion channel 3
IDBP-484614
voltage-dependent anion channel 3
IDBP-475721
voltage-dependent anion channel 3
IDBP-473458
voltage-dependent anion channel 3
IDBP-475677
voltage-dependent anion channel 3
IDBP-482488
voltage-dependent anion channel 3
IDBP-482316
voltage-dependent anion channel 3
IDBP-476397
voltage-dependent anion channel 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42391624-42405897
Strand Forward strand
Band p11.21
Transcripts
ENST00000022615 ENSP00000022615
ENST00000518563 ENSP00000428977
ENST00000520115 ENSP00000428519
ENST00000522069 ENSP00000429006
ENST00000522572 ENSP00000428029
ENST00000519072
ENST00000521348
ENST00000518495 ENSP00000430373
ENST00000521158 ENSP00000428845
ENST00000522010 ENSP00000430908
ENST00000522178
ENST00000524291
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0008308 voltage-gated anion channel activity
GO:0015288 porin activity
Biological Process
GO:0006820 anion transport
GO:0015853 adenine transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0046930 pore complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008892
View Gene Order
ENSBTAG00000014068
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04020
Calcium signaling pathway pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001135694 NM_005662
HUGO
OMIM
CCDS CCDS47850 CCDS6131
HPRD 06750
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca