InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DUSP16

Summary

InnateDB Gene

IDBG-20236.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP16

Gene Name

dual specificity phosphatase 16

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000111266

Encoded Proteins

IDBP-20238

dual specificity phosphatase 16

IDBP-20240

dual specificity phosphatase 16

IDBP-603578

dual specificity phosphatase 16

IDBP-588589

dual specificity phosphatase 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 11489891

DUSP16 mitogen activated phosphotase that negatively regulates MAPK activity and acts as a shuttle protein, determining the localization of MAPKs in the cytoplasm.

InnateDB Annotation from Orthologs

Summary

PMID 24311790

[Mus musculus] Dusp16 has a dual function in the innate immune system shaping the output of cytokines and other TLR-induced gene products by macrophages, most notably IL12, and regulating the responsiveness of bone marrow progenitor cells to the growth factor GM-CSF

Entrez Gene

Summary

This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:12474210-12562383

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000228862	ENSP00000228862
ENST00000298573	ENSP00000298573
ENST00000545864
ENST00000539940	ENSP00000443039
ENST00000541207	ENSP00000441250
ENST00000536236

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045204	MAPK export from nucleus
GO:0045209	MAPK phosphatase export from nucleus, leptomycin B sensitive

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016023	cytoplasmic membrane-bounded vesicle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030203

View Gene Order

ENSBTAG00000010763

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

p38alphabetapathway

Regulation of p38-alpha and p38-beta

Cross-References

SwissProt

TrEMBL

A0A024RAR2 F5H5X4 Q8IVT8

UniProt Splice Variant

Entrez Gene

80824

UniGene

Hs.536535

RefSeq

NM_030640 XM_006719155

HUGO

HGNC:17909

OMIM

607175

CCDS

CCDS8650

HPRD

09525

IMGT

EMBL

AB051487 AB052156 AC007619 AC092824 AF506796 BC042101 BC109235 CH471094

GenPept

AAH42101 AAI09236 AAN75120 BAB21791 BAB40814 EAW96262 EAW96263 EAW96264

RNA Seq Atlas

80824