Version 5.4
Homo sapiens Gene: SLC25A11
Summary
InnateDB Gene IDBG-20165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A11
Gene Name solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
Synonyms OGC; SLC20A4
Species Homo sapiens
Ensembl Gene ENSG00000108528
Encoded Proteins
IDBP-20169
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
IDBP-585301
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
IDBP-760908
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:4937130-4940251
Strand Reverse strand
Band p13.2
Transcripts
ENST00000225665 ENSP00000225665
ENST00000544061 ENSP00000440804
ENST00000574710
ENST00000576951 ENSP00000458993
ENST00000570543
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 26 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015367 oxoglutarate:malate antiporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006810 transport
GO:0015742 alpha-ketoglutarate transport
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014606
View Gene Order
ENSBTAG00000004910
Not yet available
Pathways
NETPATH
REACTOME
REACT_1520
Gluconeogenesis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.184877
RefSeq NM_001165417 NM_001165418 NM_003562
HUGO
OMIM
CCDS CCDS11059 CCDS54069
HPRD 05003
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca