Version 5.4
Homo sapiens Gene: EVL
Summary
InnateDB Gene IDBG-19953.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EVL
Gene Name Enah/Vasp-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196405
Encoded Proteins
IDBP-244645
Enah/Vasp-like
IDBP-295423
Enah/Vasp-like
IDBP-595717
Enah/Vasp-like
IDBP-584839
Enah/Vasp-like
IDBP-809591
Enah/Vasp-like
IDBP-584630
Enah/Vasp-like
IDBP-594320
Enah/Vasp-like
IDBP-600525
Enah/Vasp-like
IDBP-595144
Enah/Vasp-like
IDBP-588383
Enah/Vasp-like
IDBP-595813
Enah/Vasp-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:99971449-100144236
Strand Forward strand
Band q32.2
Transcripts
ENST00000392920 ENSP00000376652
ENST00000402714 ENSP00000384720
ENST00000544450 ENSP00000437904
ENST00000554460
ENST00000557023
ENST00000553771
ENST00000555706 ENSP00000450723
ENST00000555048 ENSP00000481825
ENST00000553875 ENSP00000452156
ENST00000554045 ENSP00000451226
ENST00000557637
ENST00000557153 ENSP00000452327
ENST00000556921
ENST00000557384 ENSP00000450979
ENST00000553910
ENST00000554695 ENSP00000451821
ENST00000554031 ENSP00000451761
ENST00000553799
ENST00000554518
ENST00000553694
ENST00000555999
ENST00000555606
ENST00000555848
ENST00000556258
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 22 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005522 profilin binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007015 actin filament organization
GO:0007166 cell surface receptor signaling pathway
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0008154 actin polymerization or depolymerization
GO:0009887 organ morphogenesis
GO:0010633 negative regulation of epithelial cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0046907 intracellular transport
GO:0051289 protein homotetramerization
GO:0051496 positive regulation of stress fiber assembly
GO:1900028 negative regulation of ruffle assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021262
View Gene Order
ENSBTAG00000009293
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_12623
Generation of second messenger molecules pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_12526
TCR signaling pathway
REACT_18266
Axon guidance pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3V314
UniProt Splice Variant
Entrez Gene 51466
UniGene Hs.125867 Hs.600367 Hs.733707 Hs.741513
RefSeq NM_016337 XM_006720168 XM_006720169
HUGO HGNC:20234
OMIM
CCDS CCDS9955
HPRD 10942
IMGT
EMBL AL133368 AL133523 AL157912
GenPept
RNA Seq Atlas 51466

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca