InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MINK1

Summary

InnateDB Gene

IDBG-19945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MINK1

Gene Name

misshapen-like kinase 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000141503

Encoded Proteins

IDBP-19947

misshapen-like kinase 1

IDBP-19949

misshapen-like kinase 1

IDBP-363076

misshapen-like kinase 1

IDBP-764934

IDBP-763371

IDBP-759375

IDBP-759094

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:4833388-4898061

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000347992	ENSP00000269296
ENST00000355280	ENSP00000347427
ENST00000453408	ENSP00000406487
ENST00000575511
ENST00000571207	ENSP00000459699
ENST00000572330
ENST00000571526
ENST00000576037	ENSP00000459102
ENST00000574871
ENST00000572304
ENST00000577021	ENSP00000459269
ENST00000574453	ENSP00000461500
ENST00000572629

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001952	regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0007254	JNK cascade
GO:0007268	synaptic transmission
GO:0007275	multicellular organismal development
GO:0022407	regulation of cell-cell adhesion
GO:0030334	regulation of cell migration
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0045060	negative thymic T cell selection
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048813	dendrite morphogenesis
GO:0050790	regulation of catalytic activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020827

View Gene Order

ENSBTAG00000004907

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.443417

RefSeq

NM_001024937 NM_015716 NM_153827 NM_170663 XM_005256665 XM_005256666 XM_006721534

HUGO

OMIM

CCDS

CCDS45588 CCDS45589 CCDS45590

HPRD

11366

IMGT

EMBL

GenPept

RNA Seq Atlas