InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FZD9

Summary

InnateDB Gene

IDBG-19867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD9

Gene Name

frizzled family receptor 9

Synonyms

CD349; FZD3

Species

Homo sapiens

Ensembl Gene

ENSG00000188763

Encoded Proteins

IDBP-19869

frizzled family receptor 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]
Members of the \'frizzled\' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:73433783-73436120

Strand

Forward strand

Band

q11.23

Transcripts

ENST00000344575

ENSP00000345785

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042803	protein homodimerization activity
GO:0042813	Wnt-activated receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001944	vasculature development
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007399	nervous system development
GO:0007405	neuroblast proliferation
GO:0007420	brain development
GO:0007611	learning or memory
GO:0008406	gonad development
GO:0016055	Wnt signaling pathway
GO:0030183	B cell differentiation
GO:0060070	canonical Wnt signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031527	filopodium membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000049551

View Gene Order

ENSBTAG00000020742

Not yet available

Pathways

NETPATH

NetPath_8

Wnt pathway

REACTOME

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04310

Wnt signaling pathway pathway

hsa05217

Basal cell carcinoma pathway

hsa04916

Melanogenesis pathway

hsa05200

Pathways in cancer pathway

INOH

INOH website

Wnt signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

wnt_signaling_pathway

Wnt signaling network

Cross-References

SwissProt

O00144

TrEMBL

UniProt Splice Variant

Entrez Gene

8326

UniGene

Hs.647029

RefSeq

NM_003508

HUGO

HGNC:4047

OMIM

601766

CCDS

CCDS5548

HPRD

IMGT

EMBL

AC005049 U82169

GenPept

AAC51174 AAQ93359

RNA Seq Atlas

8326